Oxidative Therapy

Oxidative Therapy

Including ozone therapy and intravenous hydrogen peroxide, introduce reactive oxygen species (ROS) into the body to induce controlled oxidative stress, intended to stimulate immune function, improve oxygen delivery, and, in cancer contexts, damage tumor cells. While proponents suggest benefits for chronic infections, arthritis, and cancer, these methods are often controversial due to limited large-scale clinical evidence and potential serious risks. 

Common Forms of Oxidative Therapy 

• Ozone (O3) Therapy: Medical-grade ozone is mixed with oxygen (O2) and administered via autohemotherapy (treating blood outside the body and reinfusing it), gas insufflation, or direct injection to modulate oxidative stress.

• Hydrogen Peroxide (H2O2) Therapy: Administered intravenously, orally, or in baths, this is used to increase tissue oxygenation, though it has risks.

• Hyperbaric Oxygen Therapy (HBOT): While distinct, HBOT uses high pressure to increase oxygen saturation in tissues to combat infection and promote healing. 

Mechanism of Action 

• Controlled Stress: Moderate, controlled exposure to ROS (oxidants) can trigger antioxidant defenses and improve cellular, particularly mitochondrial, function.

• Immune Stimulation: Ozone can trigger the release of cytokines, aiding in immune system modulation.

• Cytotoxicity: High-level oxidation, such as with enzymes generating ROS, can directly damage cancer cells. 

Risks and Safety Considerations 

• Contextual Effectiveness: While oxidative therapy aims to treat, excessive oxidative stress is associated with chronic diseases like diabetes and arthritis. 

Clinical Context

These therapies are generally considered alternative or complementary medicine. They should not be confused with conventional respiratory oxygen care. Research continues into using oxidative therapies for conditions like TMJ pain and cancer, often with mixed or preliminary results. 

References: National Institute of Health (NIH)

Cancer Network